Research Associate in Chemical Biology
Job Description
Faculty / Department
Faculty of Natural Sciences
Salary
ÂŁ48,056 – ÂŁ56,345 per annum
Location / Campus
White City Campus – On site only
Contract Type / Work Pattern
Full time – Fixed term
Closing date
04-Nov-2024
About the role
We are seeking an ambitious and creative chemical biologist to join the group of Prof Ed Tate at Imperial College, working on design and application of disruptive new technologies for novel antibody-drug conjugate (ADC) discovery. The position is available full time, starting by early 2025.
ADCs offer the potential to improve the quality of life for millions of patients by combining unprecedented efficacy with reduced side effects; they are among the fastest-growing classes of drugs, with a market expected to reach over $30 billion in the next 10 years. This is a rapidly evolving field, and ADC-related spinouts from our lab have raised over $100 million in Venture investment to date (e.g. Myricx Bio, https://myricxbio.com/).
What you would be doing
The Tate lab recently developed a powerful technology platform for de novo discovery of the critical linker component of an ADC, enabling selective release of the drug to deliver maximum therapeutic index, combining high potency with low toxicity. You will join a team of outstanding scientists in the Tate lab at Imperial’s state-of-the art £200M Molecular Sciences Research Hub, and at our recently-founded spinout company, Siftr Bio (https://www.linkedin.com/company/siftr-bio/), co-located at Imperial’s White City Campus. You will have the unique opportunity to make foundational contributions to ADC linker technology and its application to in vivo proof of concept studies, whilst collaborating with entrepreneurial innovators at a fast-moving newly formed biotech.
See the Tate group website for recent relevant papers (http://www.imperial.ac.uk/tate-group/), for example: Angew Chemie 2023, e202311190; JACS 2022, 22493; Nat Chem Biol 2021, 776; JACS 2021, 8911; ACS Chem Biol 2020, 1306. Further details will be discussed in confidence with shortlisted candidates.
What we are looking for
Essential criteria for the role include:
Hold, or be near completion of, a PhD in chemical biology, or a closely related field; or an equivalent level of professional qualifications and experience
A strong research track record relative to experience, in academia and/or industry
An interest in translating basic science toward patient benefit
Independent capability and creativity in idea generation and experimental design
Ability to mentor junior researchers, and to set and attain research objectives as part of a multidisciplinary team.
Desirable experience for this role includes one or more of the following: design and generation of ADCs or related conjugates; peptide synthesis; activity-based probe design and applications; protein biochemistry; mammalian cell culture and microscopy; handling patient tissues; proteomics and/or chemical proteomics.
What we can offer you
The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
Grow your career: Gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression
Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).
Further information
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant.
If you require any further details on the role, please contact: Prof Ed Tate – [email protected]
Available documents
Attached documents are available under links. Clicking a document link will initialize its download.
Download: Job Description Research Associate.Pdf
Download: Employee Benefits Booklet.Pdf
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.
We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.
If you encounter any technical issues while applying online, please don’t hesitate to email us at [email protected]. We’re here to help.
About Imperial
Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.
Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.
As a member of our vibrant community of 22,000 students and 8,000 staff, you’ll collaborate with passionate minds across nine London campuses and a global network.
This is your chance to help shape the future. We hope you’ll join us at Imperial College London.
Our Culture
We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our webpages.
Our values are at the root of everything we do and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.